Article
Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII.
Genomics - 1 Jun 1999
Fyfe J C, Kurzhals R L, Lassaline M E, Henthorn P S, Alur P R, Wang P, Wolfe J H, Giger U, Haskins M E, Patterson D F, Sun H, Jain S, Yuhki N
Abstract excerpt
A family of domestic cats was found that exhibited clinical and biochemical abnormalities consistent with mucopolysaccharidosis VII, an autosomal recessive lysosomal storage disorder caused by beta-glucuronidase deficiency. beta-Glucuronidase activity was undetectable in affected cat fibroblasts and restored by retroviral gene transfer of rat beta-glucuronidase cDNA. beta-Glucuronidase mRNA was normal in affected...
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