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Improving the accuracy of noninvasive prenatal testing through size‐selection between fetal and maternal cfDNA

17 Nov 2023

Abstract excerpt

OBJECTIVES: In general, fetal cfDNA is shorter than maternal cfDNA, and accuracy of noninvasive prenatal testing (NIPT) results can be improved by selecting shorter cfDNA fragments to enrich fetal-derived cfDNA. This study investigated potential improvements in the accuracy of NIPT by performing classification and analysis based on differences in cfDNA size. METHODS: We performed paired-end sequencing to identify...

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PMID: 37975672
DOI: 10.1002/pd.6464

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