Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.

PloS one - 1 Jan 2012

Pern Franziska, Bogdanova Natalia, Schürmann Peter, Lin Min, Ay Aysun, Länger Florian, Hillemanns Peter, Christiansen Hans, Park-Simon Tjoung-Won, Dörk Thilo

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive form of breast carcinoma with a poor prognosis. Recent evidence suggests that some patients with TNBC harbour germ-line mutations in DNA repair genes which may render their tumours susceptible to novel therapies such as treatment with PARP inhibitors. In the present study, we have investigated a hospital-based series of 40 German patients with TNBC for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Fanconi Anemia Complementation Group N Protein

Share to Germany

Share to Receptor, ErbB-2

Share to Receptors, Estrogen

Share to Receptors, Progesterone

Source

Open in PubMed Open full text

Identifiers

PMID: 23110154
DOI: 10.1371/journal.pone.0047993
PMCID: PMC3480465

Genes

BRCA1
PALB2
BRCA2
BRD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.PMID 23110154Read ↗

Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients.Semantic proximity Read ↗

Targeted massively parallel sequencing characterises the mutation spectrum of PALB2 in breast and ovarian cancer cases from Poland and Ukraine.Semantic proximity Read ↗

PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland.Semantic proximity Read ↗

Development of a novel PTT assay for mutation detection in PALB2 large exons and PALB2 screening in medullary breast cancer.Semantic proximity Read ↗

Prevalence of PALB2 mutation c.509_510delGA in unselected breast cancer patients from Central and Eastern Europe.Semantic proximity Read ↗

Multi-Gene Testing Overview with a Clinical Perspective in Metastatic Triple-Negative Breast Cancer.Semantic proximity Read ↗

Prevalence of BRCA1, BRCA2, and PALB2 genomic alterations among 924 Taiwanese breast cancer assays with tumor-only targeted sequencing: extended data analysis from the VGH-TAYLOR studySemantic proximity Read ↗

Prevalence of BRCA1, BRCA2, and PALB2 genomic alterations among 924 Taiwanese breast cancer assays with tumor-only targeted sequencing: extended data analysis from the VGH-TAYLOR study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.