Article
A case-control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression.
BMC cancer - 25 Oct 2012
De Feo Emma, Simone Benedetto, Persiani Roberto, Cananzi Ferdinando, Biondi Alberto, Arzani Dario, Amore Rosarita, D'Ugo Domenico, Ricciardi Gualtiero, Boccia Stefania
Abstract excerpt
BACKGROUND: Apolipoprotein E (ApoE) is a multifunctional protein playing both a key role in the metabolism of cholesterol and triglycerides, and in tissue repair and inflammation. The ApoE gene (19q13.2) has three major isoforms encoded by ε2, ε3 and ε4 alleles with the ε4 allele associated with hypercholesterolemia and the ε2 allele with the opposite effect. An inverse relationship between cholesterol levels and...
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