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Control of Breast Cancer Growth and Initiation by the Stem Cell–Associated Transcription Factor TCF3

23 Oct 2012

Abstract excerpt

Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a member of the TCF/LEF transcription factor family that is central in regulating epidermal and embryonic stem cell identity. We found that TCF3 is highly expressed in poorly differentiated human breast cancers,...

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PMID: 23090119
DOI: 10.1158/0008-5472.can-12-0119

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