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The 2009 H1N1 Pandemic Influenza Virus: What Next?

29 Sept 2010

Abstract excerpt

History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic reassortment. Going back to the late 19th century, the evolutionary histories of past pandemic viruses are examined in an effort...

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PMID: 20877580
DOI: 10.1128/mbio.00211-10

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