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Article

Evaluation of gene-obesity interaction effects on cholesterol levels: a genetic predisposition score on HDL-cholesterol is modified by obesity.

Atherosclerosis - 1 Dec 2012

Lamina Claudia, Forer Lukas, Schönherr Sebastian, Kollerits Barbara, Ried Janina S, Gieger Christian, Peters Annette, Wichmann H-Erich, Kronenberg Florian

Abstract excerpt

OBJECTIVE: Effect modification by obesity or obesity-related phenotypes (e.g. physical activity and diet) was observed in some candidate gene studies on lipids. We aimed to evaluate gene-obesity interaction effects on HDL (HDL-C), LDL (LDL-C) and total cholesterol (TC) levels using genetic predisposition scores. METHODS: We derived imputed genotypes for 104 SNPs in 84 lipid-associated loci in the population-based...

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PMID: 23058813
DOI: 10.1016/j.atherosclerosis.2012.09.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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