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Article

Early chronotype and tissue-specific alterations of circadian clock function in spontaneously hypertensive rats.

PloS one - 1 Jan 2012

Sládek Martin, Polidarová Lenka, Nováková Marta, Parkanová Daniela, Sumová Alena

Abstract excerpt

Malfunction of the circadian timing system may result in cardiovascular and metabolic diseases, and conversely, these diseases can impair the circadian system. The aim of this study was to reveal whether the functional state of the circadian system of spontaneously hypertensive rats (SHR) differs from that of control Wistar rat. This study is the first to analyze the function of the circadian system of SHR in its...

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Identifiers

PMID: 23056539
DOI: 10.1371/journal.pone.0046951
PMCID: PMC3462770

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