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Traumatic Brain Injury-Induced Dysregulation of the Circadian Clock

3 Oct 2012

Abstract excerpt

Circadian rhythm disturbances are frequently reported in patients recovering from traumatic brain injury (TBI). Since circadian clock output is mediated by some of the same molecular signaling cascades that regulate memory formation (cAMP/MAPK/CREB), cognitive problems reported by TBI survivors may be related to injury-induced dysregulation of the circadian clock. In laboratory animals, aberrant circadian rhythms...

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PMID: 23056261
DOI: 10.1371/journal.pone.0046204

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