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Identification of <i>KIF5B-RET</i> and <i>GOPC-ROS1</i> Fusions in Lung Adenocarcinomas through a Comprehensive mRNA-Based Screen for Tyrosine Kinase Fusions

11 Oct 2012

Abstract excerpt

BACKGROUND: The mutually exclusive pattern of the major driver oncogenes in lung cancer suggests that other mutually exclusive oncogenes exist. We conducted a systematic search for tyrosine kinase fusions by screening all tyrosine kinases for aberrantly high RNA expression levels of the 3' kinase domain (KD) exons relative to more 5' exons. METHODS: We studied 69 patients (including five never smokers and 64...

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PMID: 23052255
DOI: 10.1158/1078-0432.ccr-12-0838

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Identification of <i>KIF5B-RET</i> and <i>GOPC-ROS1</i> Fusions in Lung Adenocarcinomas through a Comprehensive mRNA-Based Screen for Tyrosine Kinase FusionsPMID 23052255Read ↗

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