Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS

1 Jan 2012

Abstract excerpt

2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Antimicrobial Resistance in Staphylococcus
Share to Bacterial biofilms and quorum sensing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23051988
DOI: 10.1039/c2ob26823j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQSPMID 23051988Read ↗

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicitySemantic proximity Read ↗

Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis StrainsSemantic proximity Read ↗

Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and N-Acyl-Homoserine Lactone Signaling in a Burkholderia cepacia Complex Clinical StrainSemantic proximity Read ↗

Functional Genetic Analysis Reveals a 2-Alkyl-4-Quinolone Signaling System in the Human Pathogen Burkholderia pseudomallei and Related BacteriaSemantic proximity Read ↗

PqsE is conserved and functionally relevant in <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

<b>Coumarins disrupt cell-cell communication for control of pathogenesis and virulence in ESKAPEEs and fungal opportunists</b>Semantic proximity Read ↗

The PqsE active site as a target for small molecule antimicrobial agents against <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Attenuation of Pseudomonas aeruginosa infection by INP0341, a salicylidene acylhydrazide, in a murine model of keratitisSemantic proximity Read ↗

Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine ProductionSemantic proximity Read ↗

Discovery of Antibiotic ( <i>E</i> )-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3 <i>H</i> )-oneSemantic proximity Read ↗

A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology.Semantic proximity Read ↗

High-Throughput Immunochemical Method to Assess the 2-Heptyl-4-quinolone Quorum Sensing Molecule as a Potential Biomarker of Pseudomonas aeruginosa InfectionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.