Article
A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates.
Cell transplantation - 1 Jan 2013
Bianchi Francesca, Maioli Margherita, Leonardi Erika, Olivi Elena, Pasquinelli Gianandrea, Valente Sabrina, Mendez Armando J, Ricordi Camillo, Raffaini Mirco, Tremolada Carlo, Ventura Carlo
Abstract excerpt
Adipose tissue contains multipotent elements with phenotypic and gene expression profiles similar to human mesenchymal stem cells (hMSCs) and pericytes. The chance of clinical translation of the multilineage potential of these cells is delayed by the poor/negligible cell survival within cryopreserved lipoaspirates, the difficulty of ex vivo expansion, and the complexity of current Good Manufacturing Practice...
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