Article
Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study.
Pediatric diabetes - 1 May 2013
Kanakatti Shankar Roopa, Pihoker Catherine, Dolan Lawrence M, Standiford Debra, Badaru Angela, Dabelea Dana, Rodriguez Beatriz, Black Mary Helen, Imperatore Giuseppina, Hattersley Andrew, Ellard Sian, Gilliam Lisa K
Abstract excerpt
BACKGROUND: Neonatal diabetes mellitus (NDM) is defined as diabetes with onset before 6 months of age. Nearly half of individuals with NDM are affected by permanent neonatal diabetes mellitus (PNDM). Mutations in KATP channel genes (KCNJ11, ABCC8) and the insulin gene (INS) are the most common causes of PNDM. OBJECTIVE: To estimate the prevalence of PNDM among SEARCH for Diabetes in Youth (SEARCH) study...
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