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Article

Superantigenic activity of emm3 Streptococcus pyogenes is abrogated by a conserved, naturally occurring smeZ mutation.

PloS one - 1 Jan 2012

Turner Claire E, Sommerlad Mary, McGregor Karen, Davies Frances J, Pichon Bruno, Chong Deborah L W, Farzaneh Leili, Holden Matthew T G, Spratt Brian G, Efstratiou Androulla, Sriskandan Shiranee

Abstract excerpt

Streptococcus pyogenes M/emm3 strains have been epidemiologically linked with enhanced infection severity and risk of streptococcal toxic shock syndrome (STSS), a syndrome triggered by superantigenic stimulation of T cells. Comparison of S. pyogenes strains causing STSS demonstrated that emm3 strains were surprisingly less mitogenic than other emm-types (emm1, emm12, emm18, emm28, emm87, emm89) both in vitro and...

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Identifiers

PMID: 23049698
DOI: 10.1371/journal.pone.0046376
PMCID: PMC3462185

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