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Article

De novo FUS gene mutations are associated with juvenile-onset sporadic amyotrophic lateral sclerosis in China.

Neurobiology of aging - 1 Apr 2013

Zou Zhang-Yu, Cui Li-Ying, Sun Qing, Li Xiao-Guang, Liu Ming-Sheng, Xu Yan, Zhou Yan, Yang Xun-Zhe

Abstract excerpt

Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of motor neuron disease and occurs before 25 years of age. Only very few sporadic cases of juvenile-onset ALS have been reported. Rare SOD1 mutations and several FUS mutations have been identified in juvenile-onset ALS patients. To define the genetics of juvenile-onset sporadic ALS (SALS) of Chinese origin, we sequenced all 5 exons of SOD1, exons 3-6 and...

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Source

Identifiers

PMID: 23046859
DOI: 10.1016/j.neurobiolaging.2012.09.005

Genes

FUS
SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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