Variation in genes related to obesity, weight, and weight change and risk of contralateral breast cancer in the WECARE Study population.

doi:10.1158/1055-9965.EPI-12-1036

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Article

Variation in genes related to obesity, weight, and weight change and risk of contralateral breast cancer in the WECARE Study population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2012

Brooks Jennifer D, Bernstein Leslie, Teraoka Sharon N, Knight Julia A, Mellemkjær Lene, John Esther M, Malone Kathleen E, Reiner Anne S, Lynch Charles F, Concannon Patrick, Haile Robert W, Bernstein Jonine L

Abstract excerpt

BACKGROUND: Body mass index (BMI), a known breast cancer risk factor, could influence breast risk through mechanistic pathways related to sex hormones, insulin resistance, chronic inflammation, and altered levels of adipose-derived hormones. Results from studies of the relationship between BMI and second primary breast cancer have been mixed. To explore the relationship between BMI and asynchronous contralateral...

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PMID: 23033454
DOI: 10.1158/1055-9965.EPI-12-1036
PMCID: PMC3518741

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