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Article

Down-Regulation of CDH1 Is Associated with Expression of SNAI1 in Colorectal Adenomas

28 Sept 2012

Abstract excerpt

INTRODUCTION: Down-regulation of E-cadherin (CDH1) and epithelial-mesenchymal transition (EMT) are considered critical events for invasion and metastasis of colorectal carcinoma. Here we tested whether the important regulators of E-cadherin expression SNAI1 and TWIST1 are already detectable in human colorectal adenomas. METHODS: RNA was extracted from a set of randomly selected formalin-fixed and...

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PMID: 23029563
DOI: 10.1371/journal.pone.0046665

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