Article
Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort.
PloS one - 1 Jan 2012
Alasaari Jukka S, Lagus Markus, Ollila Hanna M, Toivola Auli, Kivimäki Mika, Vahtera Jussi, Kronholm Erkki, Härmä Mikko, Puttonen Sampsa, Paunio Tiina
Abstract excerpt
BACKGROUND: Shift-working nurses are exposed to a stressful work environment, which puts them at an increased risk for burnout and depression. We explored the effect of environmental stress on serotonin transporter gene (SLC6A4) promoter methylation among nurses from high and low work stress envi...
Topics
- Adolescent
- Adult
- Base Sequence
- Burnout, Professional
- CpG Islands
- DNA Methylation
- Depression
- Female
- Genotype
- Humans
- Molecular Sequence Data
- Nurses
- Occupational Diseases
- Polymorphism, Genetic