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Article

10'(Z),13'(E)-heptadecadienylhydroquinone inhibits swarming and virulence factors and increases polymyxin B susceptibility in Proteus mirabilis.

PloS one - 1 Jan 2012

Liu Ming-Che, Lin Shwu-Bin, Chien Hsiung-Fei, Wang Won-Bo, Yuan Yu-Han, Hsueh Po-Ren, Liaw Shwu-Jen

Abstract excerpt

In this study, we demonstrated that 10'(Z), 13'(E)-heptadecadienylhydroquinone (HQ17-2), isolated from the lacquer tree, could decrease swarming motility and hemolysin activity but increase polymyxin B (PB) susceptibilityof Proteus mirabilis which is intrinsically highly-resistant to PB. The increased PB susceptibility induced by HQ17-2 was also observed in clinical isolates and biofilm-grown cells. HQ17-2 could...

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Identifiers

PMID: 23029100
DOI: 10.1371/journal.pone.0045563
PMCID: PMC3447793

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Source receipt: pubmed, retrieved 7 Sept 2026.

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