Article
Comparison between single-cell cultures and tissue cultures as model systems for evaluating the modulation of gene expression by food bioactives.
International journal of food sciences and nutrition - 1 Mar 2013
Boschetti Elisa, Bacon James R, Meyer Felicity, Tugnoli Vitaliano, Bordoni Alessandra, Kroon Paul A
Abstract excerpt
In this study, we sought the use of cultured human abdominal aortic aneurysm (AAA) tissue to investigate the transcriptional effects of some bioactives, whose role in the prevention of atherosclerotic plaque development through the regulation of gene expression has been hypothesized. After supplementation with n - 3 polyunsaturated fatty acids or epigallocatechin-3-gallate, the expression of five genes involved...
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