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Article

integIRTy: a method to identify genes altered in cancer by accounting for multiple mechanisms of regulation using item response theory.

Bioinformatics (Oxford, England) - 15 Nov 2012

Tong Pan, Coombes Kevin R

Abstract excerpt

MOTIVATION: Identifying genes altered in cancer plays a crucial role in both understanding the mechanism of carcinogenesis and developing novel therapeutics. It is known that there are various mechanisms of regulation that can lead to gene dysfunction, including copy number change, methylation, a...

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Identifiers

PMID: 23014630
DOI: 10.1093/bioinformatics/bts561
PMCID: PMC3496341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23014630-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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