Waardenburg syndrome and Hirschsprung disease: evidence for pleiotropic effects of a single dominant gene.

doi:10.1002/ajmg.1320350119

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Article

Waardenburg syndrome and Hirschsprung disease: evidence for pleiotropic effects of a single dominant gene.

American journal of medical genetics - 1 Jan 1990

Badner J A, Chakravarti A

Abstract excerpt

Segregation and linkage analysis was performed on published data on 5 families segregating for Waardenburg syndrome (WS) and Hirschsprung disease (HRSD). Two of these families demonstrated parental consanguinity. On the basis of these families, autosomal recessive inheritance of the combination W...

Topics

Abnormalities, Multiple
Crossing Over, Genetic
Genes, Dominant
Genetic Linkage
Hirschsprung Disease
Humans
Models, Genetic
Phenotype
Waardenburg Syndrome

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