Major-locus contributions to variability of the craniofacial feature dystopia canthorum in Waardenburg syndrome.

Article

Major-locus contributions to variability of the craniofacial feature dystopia canthorum in Waardenburg syndrome.

American journal of human genetics - 1 Feb 1996

Reynolds J E, Marazita M L, Meyer J M, Stevens C A, Eaves L J, Arnos K S, Ploughman L M, MacLean C, Nance W E, Diehl S R

Abstract excerpt

We used segregation analysis to investigate the genetic basis of variation in dystopia canthorum, one of the key diagnostic features of Waardenburg syndrome type 1 (WS1). We sought to determine whether the W-index, a quantitative measure of this craniofacial feature, is influenced primarily eithe...

Topics

Alleles
Deafness
Eyelids
Facies
Humans
Phenotype
Waardenburg Syndrome

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