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Article

Detection of monosomy 7 in interphase cells of patients with myeloid disorders.

American journal of hematology - 1 Feb 1990

Kolluri R V, Manuelidis L, Cremer T, Sait S, Gezer S, Raza A

Abstract excerpt

Six patients, five with acute myeloid leukemia (AML) and one with a myelodysplastic syndrome (MDS), were found to have monosomy 7 by conventional cytogenetics at diagnosis. Repetitive DNA sequences from the heterochromatic region of human chromosomes 1 and 7 were used as probes for in situ hybridization experiments on interphase cells of these patients. A double hybridization protocol was used to reveal the...

Topics

Chromosome Deletion
Chromosome Mapping
DNA
Humans
Interphase
Leukemia, Monocytic, Acute
Metaphase
Monosomy
Myelodysplastic Syndromes
Nucleic Acid Hybridization
Phenotype

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Identifiers

PMID: 2301370
DOI: 10.1002/ajh.2830330208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2301370-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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