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Article

LINE1 family member is negative regulator of HLA-G expression

21 Sept 2012

Abstract excerpt

Class Ia molecules of human leucocyte antigen (HLA-A, -B and -C) are widely expressed and play a central role in the immune system by presenting peptides derived from the lumen of the endoplasmic reticulum. In contrast, class Ib molecules such as HLA-G serve novel functions. The distribution of HLA-G is mostly limited to foetal trophoblastic tissues and some tumour tissues. The mechanism required for the...

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PMID: 23002136
DOI: 10.1093/nar/gks874

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