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Article

Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2013

Shu Catherine, Cheng Haiying, Wang Antai, Mansukhani Mahesh M, Powell Charles A, Halmos Balazs, Borczuk Alain C

Abstract excerpt

Thymidylate synthase expression is known to be higher in squamous cell carcinoma than in adenocarcinoma of the lung. It is thought that this is the reason for the poor efficacy of pemetrexed in squamous cell carcinoma. However, there is limited data on thymidylate synthase expression in adenosquamous carcinoma, a distinct subtype of lung cancer containing both squamous and glandular differentiation. Furthermore,...

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PMID: 22996376
DOI: 10.1038/modpathol.2012.158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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