Article
Screening for VPS35 mutations in Parkinson's disease.
Neurobiology of aging - 1 Apr 2012
Sheerin Una-Marie, Charlesworth Gavin, Bras Jose, Guerreiro Rita, Bhatia Kailash, Foltynie Thomas, Limousin Patricia, Silveira-Moriyama Laura, Lees Andrew, Wood Nicholas
Abstract excerpt
Recently 2 groups have independently identified a mutation in the gene 'vacuolar protein sorting 35 homolog' (VPS35 c.1858G>A; p.Asp620Asn) as a possible cause of autosomal dominant Parkinson's disease (PD). In order to assess the frequency of the reported mutation and to search for other possible disease-causing variants in this gene, we sequenced all 17 exons of VPS35 in 96 familial PD cases, and exon 15 (in...
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