Article
Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.
Neurobiology of disease - 1 Jan 2013
Russell Aaron P, Wada Shogo, Vergani Lodovica, Hock M Benjamin, Lamon Séverine, Léger Bertrand, Ushida Takashi, Cartoni Romain, Wadley Glenn D, Hespel Peter, Kralli Anastasia, Soraru Gianni, Angelini Corrado, Akimoto Takayuki
Abstract excerpt
Skeletal muscle mitochondrial dysfunction is believed to play a role in the progression and severity of amyotrophic lateral sclerosis (ALS). The regulation of transcriptional co-activators involved in mitochondrial biogenesis and function in ALS is not well known. When compared with healthy control subjects, patients with ALS, but not neurogenic disease (ND), had lower levels of skeletal muscle peroxisome...
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