Article
Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs.
Pharmacogenomics - 1 Sept 2012
Verhoef Talitha I, Redekop William K, van Schie Rianne Mf, Bayat Samira, Daly Ann K, Geitona Mary, Haschke-Becher Elisabeth, Hughes Dyfrig A, Kamali Farhad, Levin Lars-Åke, Manolopoulos Vangelis G, Pirmohamed Munir, Siebert Uwe, Stingl Julia C, Wadelius Mia, de Boer Anthonius, Maitland-van der Zee Anke-Hilse
Abstract excerpt
Genotyping patients for CYP2C9 and VKORC1 polymorphisms can improve the accuracy of dosing during the initiation of anticoagulation with vitamin K antagonists (coumarin derivatives). The anticipated degree of improvement in the safety of anticoagulation with coumarins through genotyping may vary depending on the quality of patient care, which varies both with and among countries. The management and the cost of...
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