Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of mammalian target of rapamycin with aggressive type II endometrial carcinomas and poor outcome: a potential target treatment.

Human pathology - 1 Feb 2013

Peiró Gloria, Peiró Francisca M, Ortiz-Martínez Fernando, Planelles María, Sánchez-Tejada Laura, Alenda Cristina, Ceballos Segundo, Sánchez-Payá José, Laforga Juan B

Abstract excerpt

The classification of endometrial carcinoma divided into types I and II has shown clinical usefulness. Molecular alterations of PTEN and Wnt/β-catenin have been identified in this neoplasia. However, the role of mammalian target of rapamycin according to subcellular localization in the pathogenesis of this neoplasia and its prognostic significance are not well defined. We studied the expression of phosphorylated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Endometrioid
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Microsatellite Instability

Share to PTEN Phosphohydrolase

Share to Sirolimus

Share to Tissue Array Analysis

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 22955108
DOI: 10.1016/j.humpath.2012.05.008

Genes

PTEN
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of mammalian target of rapamycin with aggressive type II endometrial carcinomas and poor outcome: a potential target treatment.PMID 22955108Read ↗

p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humansSemantic proximity Read ↗

Activation of PI3K/Akt/mTOR pathway and dual inhibitors of PI3K and mTOR in endometrial cancer.Semantic proximity Read ↗

Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability.Semantic proximity Read ↗

Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer.Semantic proximity Read ↗

MicroRNA-199a-3p Regulates Endometrial Cancer Cell Proliferation by Targeting Mammalian Target of Rapamycin (mTOR)Semantic proximity Read ↗

Enhanced nuclear Y-box binding protein-1 expression predicts poor prognosis in close association with mammalian target of rapamycin expression in endometrial cancerSemantic proximity Read ↗

Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3β signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cellsSemantic proximity Read ↗

Coexistent <i>PTEN</i> and <i>PIK3CA</i> alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibitionSemantic proximity Read ↗

Loss of PTEN expression is an independent predictor of favourable survival in endometrial carcinomasSemantic proximity Read ↗

Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1Semantic proximity Read ↗

Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinomaSemantic proximity Read ↗

Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.