Article
Dominant incidence of multidrug and extensively drug-resistant specific Mycobacterium tuberculosis clones in Osaka Prefecture, Japan.
PloS one - 1 Jan 2012
Tamaru Aki, Nakajima Chie, Wada Takayuki, Wang Yajun, Inoue Manabu, Kawahara Ryuji, Maekura Ryoji, Ozeki Yuriko, Ogura Hisashi, Kobayashi Kazuo, Suzuki Yasuhiko, Matsumoto Sohkichi
Abstract excerpt
Infection and transmission of multidrug-resistant Mycobacterium tuberculosis (MDR-Mtb) and extensively drug-resistant M. tuberculosis (XDR-Mtb) is a serious health problem. We analyzed a total of 1,110 Mtb isolates in Osaka Prefecture and neighboring areas from April 2000 to March 2009. A total of 89 MDR-Mtb were identified, 36 (48.5%) of which were determined to be XDR-Mtb. Among the 89 MDR-Mtb isolates, 24...
Topics
- Cluster Analysis
- Extensively Drug-Resistant Tuberculosis
- Genetic Variation
- Genotype
- Humans
- Incidence
- Japan
- Microbial Sensitivity Tests
- Models, Genetic
- Mutation
- Mycobacterium tuberculosis
- Phylogeny
- Public Health