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Article

Effects of a buried cysteine-to-serine mutation on yeast triosephosphate isomerase structure and stability.

International journal of molecular sciences - 1 Jan 2012

Hernández-Santoyo Alejandra, Domínguez-Ramírez Lenin, Reyes-López César A, González-Mondragón Edith, Hernández-Arana Andrés, Rodríguez-Romero Adela

Abstract excerpt

All the members of the triosephosphate isomerase (TIM) family possess a cystein residue (Cys126) located near the catalytically essential Glu165. The evolutionarily conserved Cys126, however, does not seem to play a significant role in the catalytic activity. On the other hand, substitution of th...

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Source

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Identifiers

PMID: 22949845
DOI: 10.3390/ijms130810010
PMCID: PMC3431843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22949845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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