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UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages

30 Aug 2012

Abstract excerpt

UVA (320-400 nm) represents the main spectral component of solar UV radiation, induces pre-mutagenic DNA lesions and is classified as Class I carcinogen. Recently, discussion arose whether UVA induces DNA double-strand breaks (dsbs). Only few reports link the induction of dsbs to UVA exposure and the underlying mechanisms are poorly understood. Using the Comet-assay and γH2AX as markers for dsb formation, we...

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PMID: 22941639
DOI: 10.1093/nar/gks824

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