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Article

CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori -related carcinogenesis

30 Aug 2012

Abstract excerpt

OBJECTIVE: MicroRNAs (miRNAs) act as tumour suppressor genes or oncogenes in the regulation of multiple carcinogenic processes. Aberrant miRNA expression is reported in Helicobacter pylori (H pylori)-related gastritis and gastric cancer. The cytotoxin-associated gene A (CagA) of H pylori has a pathophysiologically important role in gastric carcinogenesis. A study was undertaken to evaluate the effect of CagA on...

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PMID: 22936674
DOI: 10.1136/gutjnl-2011-301625

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