Article
Selection at the GSDMC locus in horses and its implications for human mobility.
Science (New York, N.Y.) - 28 Aug 2025
Liu Xuexue, Jia Yaozhen, Pan Jianfei, Zhang Yanli, Gong Ying, Wang Xintong, Ma Yuehui, Alvarez Nadir, Jiang Lin, Orlando Ludovic
Abstract excerpt
Horsepower revolutionized human history through enhanced mobility, transport, and warfare. However, the suite of biological traits that reshaped horses during domestication remains unclear. We scanned an extensive horse genome time series for selection signatures at 266 markers associated with key traits. We detected a signature of positive selection at ZFPM1-known to be a modulator of behavior in mice-occurring...
Read the complete abstract on PubMedTopics
- Animals
- Humans
- Mice
- Domestication
- Genotype
- Horses
- Muscle Strength