Article
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Genes, chromosomes & cancer - 1 Dec 2012
Poeta Maria Luana, Massi Emanuela, Parrella Paola, Pellegrini Pasquale, De Robertis Mariangela, Copetti Massimiliano, Rabitti Carla, Perrone Giuseppe, Muda Andrea Onetti, Molinari Francesca, Zanellato Elena, Crippa Stefano, Caputo Damiano, Caricato Marco, Frattini Milo, Coppola Roberto, Fazio Vito Michele
Abstract excerpt
Epigenetic alterations, such as CpG islands methylation and histone modifications, are recognized key characteristics of cancer. Glycogenes are a group of genes which epigenetic status was found to be changed in several tumors. In this study, we determined promoter methylation status of the glycogene beta-1,4-galactosyltransferase 1 (B4GALT1) in colorectal cancer patients. Methylation status of B4GALT1 was...
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