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Article

ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population.

PloS one - 1 Jan 2012

Lahut Suna, Ömür Özgür, Uyan Özgün, Ağım Zeynep Sena, Özoğuz Aslihan, Parman Yeşim, Deymeer Feza, Oflazer Piraye, Koç Filiz, Özçelik Hilmi, Auburger Georg, Başak A Nazlı

Abstract excerpt

Expansions of the polyglutamine (polyQ) domain (≥ 34) in Ataxin-2 (ATXN2) are the primary cause of spinocerebellar ataxia type 2 (SCA2). Recent studies reported that intermediate-length (27-33) expansions increase the risk of Amyotrophic Lateral Sclerosis (ALS) in 1-4% of cases in diverse populations. This study investigates the Turkish population with respect to ALS risk, genotyping 158 sporadic, 78 familial...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22916186
DOI: 10.1371/journal.pone.0042956
PMCID: PMC3423429

Genes

ATXN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population.PMID 22916186Read ↗

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