Article
The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals.
PloS one - 1 Jan 2012
Jung Kwonil, Wang Qiuhong, Kim Yunjeong, Scheuer Kelly, Zhang Zhenwen, Shen Quan, Chang Kyeong-Ok, Saif Linda J
Abstract excerpt
The lack of an animal model for human norovirus (HuNoV) has hindered the development of therapeutic strategies. This study demonstrated that a commonly used cholesterol-lowering statin medication, simvastatin, which increases HuNoV replication in an in vitro replicon system, also enhances HuNoV infectivity in the gnotobiotic (Gn) pig model. In contrast, oral treatment with interferon (IFN)-α reduces HuNoV...
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