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Article

In vivo selection of rifamycin-resistant Clostridium difficile during rifaximin therapy.

Antimicrobial agents and chemotherapy - 1 Nov 2012

Carman Robert J, Boone James H, Grover Harish, Wickham Kimberly N, Chen Li

Abstract excerpt

We report the selection of Clostridium difficile resistant to the rifamycin class of antibiotics in a patient within 32 h of receiving rifaximin for the treatment of recurrent C. difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB.

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Identifiers

PMID: 22908175
DOI: 10.1128/AAC.00974-12
PMCID: PMC3486587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22908175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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