Article
Differentiation in quinolone resistance by virulence genotype in Pseudomonas aeruginosa.
PloS one - 1 Jan 2012
Agnello Melissa, Wong-Beringer Annie
Abstract excerpt
Pseudomonas aeruginosa is a leading pathogen that has become increasingly resistant to the fluoroquinolone antibiotics due to widespread prescribing. Adverse outcomes have been shown for patients infected with fluoroquinolone-resistant strains. The type III secretion system (TTSS) is a major virulence determinant during acute infections through the injection of effector toxins into host cells. Most strains...
Topics
- ADP Ribose Transferases
- Bacterial Proteins
- Bacterial Toxins
- Drug Resistance, Bacterial
- Fluoroquinolones
- Genotype
- Humans
- Microbial Sensitivity Tests
- Mutation
- Phenotype
- Pneumonia
- Pseudomonas Infections