Article
A novel function for the competence inducing peptide, XIP, as a cell death effector of Streptococcus mutans.
FEMS microbiology letters - 1 Nov 2012
Wenderska Iwona B, Lukenda Nikola, Cordova Martha, Magarvey Nathan, Cvitkovitch Dennis G, Senadheera Dilani B
Abstract excerpt
In Streptococcus mutans, ComX, an alternative sigma factor, drives the transcription of the 'late-competence genes' required for genetic transformation. ComX activity is modulated by inputs from two signaling pathways, ComDE and ComRS, that respond to the competence-stimulating peptide (CSP) and the SigX-inducing peptide (XIP), respectively. In particular, the comRS, encoding the ComR regulatory protein and the...
Topics
- Bacterial Proteins
- Base Sequence
- Culture Media
- Gene Expression Regulation, Bacterial
- Gene Order
- Models, Biological
- Mutation
- Peptides
- Signal Transduction
- Streptococcus mutans