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Article

[Screening for cytotoxic defects with flow cytometric detection of CD107α on natural killer cells and cytotoxic lymphocyte cells].

Zhonghua er ke za zhi = Chinese journal of pediatrics - 1 May 2012

Wang Jing, Liu Zheng, Jiang Li-ping, An Yun-fei, Zhao Xiao-dong

Abstract excerpt

OBJECTIVE: To establish a novel flow cytometry-based assay for measuring the expression of lysosomal-associated membrane protein 1 (LAMP-1, CD107α) on the cell surface of natural killer (NK) cells and cytotoxic T lymphocyte (CTL) and evaluate the screening value of this assay for cytotoxic defects-related diseases such as familial hemophagocytic lymphopro-liferative (FHL) syndrome. METHOD: Three suspected...

Read the complete abstract on PubMed

Topics

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Share to Cell Degranulation
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Killer Cells, Natural

Share to Lymphohistiocytosis, Hemophagocytic

Share to Lysosomal-Associated Membrane Protein 1

Share to Phytohemagglutinins

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 22883044

Genes

LYST
STX11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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