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Blood Cell Mitochondrial DNA Content and Premature Ovarian Aging

3 Aug 2012

Abstract excerpt

Primary ovarian insufficiency (POI) is a critical fertility defect characterized by an anticipated and silent impairment of the follicular reserve, but its pathogenesis is largely unexplained. The frequent maternal inheritance of POI together with a remarkable dependence of ovarian folliculogenesis upon mitochondrial biogenesis and bioenergetics suggested the possible involvement of a generalized mitochondrial...

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PMID: 22879975
DOI: 10.1371/journal.pone.0042423

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