Article
WSC-1 and HAM-7 are MAK-1 MAP kinase pathway sensors required for cell wall integrity and hyphal fusion in Neurospora crassa.
PloS one - 1 Jan 2012
Maddi Abhiram, Dettman Anne, Fu Ci, Seiler Stephan, Free Stephen J
Abstract excerpt
A large number of cell wall proteins are encoded in the Neurospora crassa genome. Strains carrying gene deletions of 65 predicted cell wall proteins were characterized. Deletion mutations in two of these genes (wsc-1 and ham-7) have easily identified morphological and inhibitor-based defects. Their phenotypic characterization indicates that HAM-7 and WSC-1 function during cell-to-cell hyphal fusion and in cell...
Topics
- Cell Wall
- DNA Mutational Analysis
- Enzyme Activation
- Fungal Proteins
- Gene Deletion
- Genetic Complementation Test
- Histidine Kinase
- Hyphae
- MAP Kinase Signaling System
- Membrane Fusion
- Mutant Proteins