Article
Cross-reacting antibacterial auto-antibodies are produced within coronary atherosclerotic plaques of acute coronary syndrome patients.
PloS one - 1 Jan 2012
Canducci Filippo, Saita Diego, Foglieni Chiara, Piscopiello Maria Rosaria, Chiesa Roberto, Colombo Antonio, Cianflone Domenico, Maseri Attilio, Clementi Massimo, Burioni Roberto
Abstract excerpt
Coronary atherosclerosis, the main condition predisposing to acute myocardial infarction, has an inflammatory component caused by stimuli that are yet unknown. We molecularly investigated the nature of the immune response within human coronary lesion in four coronary plaques obtained by endoluminal atherectomy from four patients. We constructed phage-display libraries containing the IgG1/kappa antibody fragments...
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