Article
Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach.
Journal of child psychology and psychiatry, and allied disciplines - 1 Feb 2013
Georgiades Stelios, Szatmari Peter, Boyle Michael, Hanna Steven, Duku Eric, Zwaigenbaum Lonnie, Bryson Susan, Fombonne Eric, Volden Joanne, Mirenda Pat, Smith Isabel, Roberts Wendy, Vaillancourt Tracy, Waddell Charlotte, Bennett Teresa, Thompson Ann
Abstract excerpt
BACKGROUND: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which is often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On the basis of empirical evidence, instead of three binary categories, the upcoming edition of the DSM 5 will use two dimensions - social communication deficits (SCD) and fixated interests and repetitive behaviors...
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