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Article

Lipid-lowering effect of fluvastatin in relation to cytochrome P450 2C9 variant alleles frequently distributed in the Czech population.

Medical science monitor : international medical journal of experimental and clinical research - 1 Aug 2012

Buzková Helena, Pechandová Kristina, Danzig Vilém, Vareka Tomá, Perlik Frantisek, Zak Ales, Slanar Ondrej

Abstract excerpt

BACKGROUND: CYP2C9*3 allele has been reported to correlate with increased plasma concentration of fluvastatin active form in healthy volunteers. We analyzed the correlation between the CYP2C9 genotype and cholesterol-lowering effect of fluvastatin in human hypercholesterolemic patients. MATERIAL/METHODS: The study was prospective, without any interventions to standard procedures of hypolipidemic treatment. CYP2C9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22847201
DOI: 10.12659/msm.883272
PMCID: PMC3560696

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