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Article

Circulating microparticles from patients with obstructive sleep apnea enhance vascular contraction: mandatory role of the endothelium.

The American journal of pathology - 1 Oct 2012

Tual-Chalot Simon, Fatoumata Keita, Priou Pascaline, Trzepizur Wojciech, Gaceb Abderahim, Contreras Cristina, Prieto Dolores, Martinez Maria Carmen, Gagnadoux Frédéric, Andriantsitohaina Ramaroson

Abstract excerpt

Obstructive sleep apnea (OSA) is characterized by repetitive apnea-hypopnea cycles during sleep associated with oxygen desaturation and sleep disruption. We evaluated the role of circulating microparticles (MPs) from patients with OSA in the regulation of vascular function. MPs from whole blood from patients with OSA or control subjects were injected i.v. into mice. Injection of MPs from patients with OSA induced...

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PMID: 22846722
DOI: 10.1016/j.ajpath.2012.06.020

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