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Article

Molecular functions of metallothionein and its role in hematological malignancies

27 Jul 2012

Abstract excerpt

Metallothionein (MT) was reported to be a potential negative regulator of apoptosis, and various reports have suggested that it may play roles in carcinogenesis and drug resistance, in at least a portion of cancer cells. The author summarizes the current understanding of the molecular functions of MT for tumor cell growth and drug resistance. These activities are regulated through intracellular metal ion...

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PMID: 22839501
DOI: 10.1186/1756-8722-5-41

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