Article
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy.
Translational psychiatry - 13 Mar 2012
Almeida S S, Naffah-Mazzacoratti M G, Guimarães P B, Wasinski F, Pereira F E G, Canzian M, Centeno R S, Carrete H, Yacubian E M, Carmona A K, Vieira R F F, Nakaie C R, Sabatini R A, Perosa S R, Bacurau R F P, Gouveia T L F, Gallo G, Würtele M, Cavalheiro E A, Silva J A, Pesquero J B, Araujo R C
Abstract excerpt
We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between...
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